About 10% of penicillin-sensitive patients will also be allergic to cephalosporins and therefore, great care should be taken if cephalexin is given to patients known to be hypersensitive to penicillin.
Reduced dosage is recommended in patients with severe renal impairment.
The urine of patients taking cephalexin may give false positive reaction for glucose with copper reduction reagents. Positive results to the Coombs' test have been reported with cephalexin and these can interfere with blood-cross matching.
Use in pregnancy & lactation: Cephalexin crosses the placenta and small quantities are found in the milk of nursing mothers.